P6249

p53 human

recombinant, expressed in E. coli, buffered aqueous glycerol solution

• UNSPSC 코드: 12352202
• NACRES: NA.25

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 분석: ≥90% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• UniProt 수납 번호: P04637
• 응용 분야: genomic analysis
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... TP53(7157)

설명

일반 설명

p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.

애플리케이션

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

생화학적/생리학적 작용

p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.

물리적 특성

GST-tagged, full-length human p53

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable