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Merck
모든 사진(1)

주요 문서

M0199

Sigma-Aldrich

Mdivi-1

≥98% (HPLC), powder, mitochondrial division DRP inhibitor

동의어(들):

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone

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About This Item

실험식(Hill 표기법):
C15H10Cl2N2O2S
CAS Number:
Molecular Weight:
353.22
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

Product Name

Mdivi-1, ≥98% (HPLC), powder

Quality Level

분석

≥98% (HPLC)

양식

powder

색상

white to beige

solubility

DMSO: >20 mg/mL

배송 상태

wet ice

저장 온도

−20°C

SMILES string

COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl

InChI

1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI key

NZJKEVWTYMOYOR-UHFFFAOYSA-N

관련 카테고리

일반 설명

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

애플리케이션

Mdivi-1 has been used:
  • in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation
  • in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)
  • to induce mitochondrial damage in lung fibroblasts

생화학적/생리학적 작용

Mdivi-1 is a cell-permeable selective inhibitor of mitochondrial division DRP (dynamin-related GTPase) and inhibitor of the mitochondrial division dynamin (Dnm1). Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.
Mdivi-1 is a selective inhibitor of mitochondrial division DRP (dynamin-related GTPase); inhibitor of the mitochondrial division dynamin (Dnm1).

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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