PZ0394

PF-05212377 succinate

≥98% (HPLC)

• 동의어(들): 2-Methyl-1-(phenylsulfonyl)-4-piperazin-1-yl-1H-benzimidazole, succinate salt, PF 05212377 succinate, PF 5212377 succinate, PF-5212377 succinate, PF05212377 succinate, PF5212377 succinate, SAM-760 succinate, WYE-103760 succinate
• 실험식(Hill 표기법): C₁₈H₂₀N₄O₂S · xC₄H₆O₄
• Molecular Weight: 356.44 (free base basis)
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: room temp

설명

생화학적/생리학적 작용

PF-05212377 (SAM-760; WYE-103760) is an orally available, high-affinity, selective 5-hydroxytryptamine (5-HT; serotonin) receptor 5-HT6 antagonist (K_i/IC₅₀ = 0.53/1.06 nM against 3 nM [3H]-LSD for binding human 5-HT6). PF-05212377 modulates glutamate and acetylcholine release in the cerebral cortex and hippocampus in rodents with in vivo pro-cognitive efficacy.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable