R108

Ro 41-0960

solid

• 동의어(들): 2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
• 실험식(Hill 표기법): C₁₃H₈FNO₅
• CAS Number: 125628-97-9
• Molecular Weight: 277.20
• MDL number: MFCD00078597
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278193
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 100
• 저장 조건: protect from light
• 색상: yellow
• solubility: H₂O: slightly soluble <0.7 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL; ethanol: soluble
• 저장 온도: 2-8°C
• SMILES string: Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F
• InChI: 1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H
• InChI key: RQPAUNZYTYHKHA-UHFFFAOYSA-N
• 유전자 정보: human ... COMT(1312)

설명

애플리케이션

Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.

생화학적/생리학적 작용

Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.

특징 및 장점

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

Store tightly sealed at 4 °C, protected from exposure to light.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)