S5576

SKA-31

≥98% (HPLC)

• 동의어(들): Naphtho[1,2-d]thiazol-2-ylamine
• 실험식(Hill 표기법): C₁₁H₈N₂S
• CAS Number: 40172-65-4
• Molecular Weight: 200.26
• MDL number: MFCD00051329
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329824457
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• solubility: DMSO: ≥30 mg/mL
• 저장 온도: −20°C
• SMILES string: Nc1nc2c(ccc3ccccc23)s1
• InChI: 1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
• InChI key: FECQXVPRUCCUIL-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels.

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC₅₀ is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.

SKA31 is an activator of KCa2 and KCa3.1

SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H319
• 예방조치 성명서: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable