T6700

TRAM-34

≥98% (HPLC), solid

• 동의어(들): 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
• 실험식(Hill 표기법): C₂₂H₁₇ClN₂
• CAS Number: 289905-88-0
• Molecular Weight: 344.84
• MDL number: MFCD09842562
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826852
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: off-white
• solubility: DMSO: 2 mg/mL; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
• InChI: 1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
• InChI key: KBFUQFVFYYBHBT-UHFFFAOYSA-N

설명

애플리케이션

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

생화학적/생리학적 작용

TRAM-34 exhibits 100-fold selectivity (K_d = 20 nM) for IK_Ca1 channels over other K⁺ channels (Charybdotoxin, K_d = 5 nM, Clotrimazole, K_d = 70 nM; Nitrendipine K_d = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel.

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H413
• 예방조치 성명서: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves