S9446

Sphingosine Kinase 1 human

aqueous glycerol solution

• 동의어(들): SPHK 1
• EC 번호: 2.7.1.91 (BRENDA, IUBMB)
• MDL number: MFCD09265456
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 재조합: expressed in baculovirus infected insect cells
• Quality Level: 200
• 양식: solution
• 특이 활성도: ≥10 units/μg
• 분자량: 47 kDa
• UniProt 수납 번호: Q9NYA1
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... SPHK1(8877)

설명

일반 설명

Sphingosine 1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.

애플리케이션

Sphingosine kinase 1 has been used in a study to assess the modulation of cellular S1P levels. Sphingosine kinase 1 has also been used in a study to investigate how FTY720 normalizes hyperglycemia.

생화학적/생리학적 작용

Converts sphingosine to sphingosine-1-phosphate. SPHK1 shares two large conserved regions with SPHK2. While SPHK1 is found only in the cytosol, SPHK2 is localized in both the cytosol and nuclei.

단위 정의

One unit will produce 1.0 pmole of sphingosine-1-phosphate from ATP and D-erythro-sphingosine per minute at pH 7.4, 37 °C.

물리적 형태

Supplied in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween 20, 50% glycerol, 3 mM DTT.

aqueous glycerol solution

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)