SBR00017

Puromycin aminonucleoside Ready Made Solution

10 mg/mL in water

• 동의어(들): 3′-Amino-3′-deoxy-N⁶,N⁶-dimethyladenosine
• 실험식(Hill 표기법): C₁₂H₁₈N₆O₃
• CAS Number: 58-60-6
• Molecular Weight: 294.31
• UNSPSC 코드: 51281912
• NACRES: NA.85

속성

• 분석: ≥98%
• Quality Level: 200
• 양식: liquid
• 농도: 10 mg/mL in water
• 항생제 활성 스펙트럼: Gram-positive bacteria; neoplastics; parasites
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: N[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C)C)=NC=N3)O[C@@H]1CO
• InChI: 1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3
• InChI key: RYSMHWILUNYBFW-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Puromycin aminonucleoside is an aminonucleoside derivative of the known antibiotic puromycin. Puromycin aminonucleoside has been used in nephrology research, studying focal and segmental glomerulosclerosis, and in the induction of nephrosis in rats. Rats with puromycin aminonucleoside-induced nephrotic syndrome were used to study the excretion of sodium and NO_x metabolites.

Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).

제조 메모

Puromycin aminonucleoside solution is provided at 10 mg/mL in water and could be further diluted in aqueous buffers to a working concentration of 10 μg/mL (1:1000).

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable