SML1009

PFK15

≥98% (HPLC)

• 동의어(들): 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
• 실험식(Hill 표기법): C₁₇H₁₂N₂O
• CAS Number: 4382-63-2
• Molecular Weight: 260.29
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3
• InChI: 1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
• InChI key: UJJUKZPBUMCSJZ-BQYQJAHWSA-N

설명

애플리케이션

PFK15, a PFKFB3 inhibitor has been used to investigate its effects on the modulation of autophagy and proliferation in rhabdomyosarcoma (RD) cells.

생화학적/생리학적 작용

PFK15 is also referred as 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one. It prevents autophagy and multiplication in rhabdomyosarcoma cells. PFK15 results in cell death in gastric cancer cells via mitochondrial pathway. It also blocks MKN45 (human gastric cancer cell lines) tumor growth in vivo. PFK15 promotes cell cycle arrest and changes the upregulation of key cell cycle proteins.

PFK15 is potent and selective antagonist of PFKB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3) that causes a rapid induction of apoptosis in cancer and transformed cells. PFK15 inhibits the growth of LLC xenografts.

PFK15 is potent and selective antagonist of PFKB3.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable