SML1225
Indisulam
≥98% (HPLC)
동의어(들):
N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide, N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C14H12ClN3O4S2
CAS Number:
Molecular Weight:
385.85
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to pink
solubility
DMSO: 20 mg/mL, clear
저장 온도
−20°C
SMILES string
ClC1=CNC2=C1C=CC=C2NS(C3=CC=C(S(=O)(N)=O)C=C3)(=O)=O
InChI
1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
InChI key
SETFNECMODOHTO-UHFFFAOYSA-N
관련 카테고리
생화학적/생리학적 작용
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor.
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.
Indisulam is synthetic sulfonamide compound. In vitro and in vivo studies point out that indisulam prevents retinoblastoma protein phosphorylation. Also, it inhibits cyclins A and B1 activity. Indisulam is known to promote apoptosis. Indisulam is a potent inhibitor of cellular dehydrogenases and thus, is likely to interfere with metabolic pathways such as malate-aspartate shuttle, glycolysis and gluconeogenesis.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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