SML1741
TH1020
≥95% (HPLC)
동의어(들):
4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3′,2′,4,5]-thieno[3,2-d]pyrimidine, 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C23H15N7S2
CAS Number:
Molecular Weight:
453.54
UNSPSC 코드:
51111800
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥95% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 3 mg/mL, clear (warmed)
저장 온도
2-8°C
SMILES string
C1(C2=CC=NC=C2)=NN=C(SC3=NC=NC4=C3SC5=C4C=CC=N5)N1CC6=CC=CC=C6
InChI
1S/C23H15N7S2/c1-2-5-15(6-3-1)13-30-20(16-8-11-24-12-9-16)28-29-23(30)32-22-19-18(26-14-27-22)17-7-4-10-25-21(17)31-19/h1-12,14H,13H2
InChI key
CBBXTGWSGPEJEE-UHFFFAOYSA-N
애플리케이션
TH1020 has been used to inhibit toll-like receptor 5 (TLR5) in porcine intestinal epithelial monolayer cells and mice.
생화학적/생리학적 작용
TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor.
TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor. TH1020 selectively prevents flagellin-induced TLR5 signaling without affecting ligands-induced activation of TLR2, TLR3, TLR4, TLR7 or TLR8.
TH1020 mediates the inhibition of tumor necrosis factor-α (TNF-α) based signaling, It disrupts tetrameric complex by binding the molecular interface between dimeric TLR5.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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