SML2075

Gimeracil

≥98% (HPLC)

• 동의어(들): 5-Chloropyridine-2,4-diol, 5-chloro-4-hydroxypyridin-2(1H)-one, CDHP, Gimestat
• 실험식(Hill 표기법): C₅H₄ClNO₂
• CAS Number: 103766-25-2
• Molecular Weight: 145.54
• MDL number: MFCD08458352
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to brown
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: Clc1c[nH][c](cc1O)=O
• InChI: 1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
• InChI key: ZPLQIPFOCGIIHV-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Gimeracil (5-chloro-2, 4-dihydroxypyridine) is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine and the chemotherapeutic drug 5-fluorouracil (5FU). Gimeracil is shown to exhibit cancer-radiosensitizing efficacy in cultures in vitro (1 mM) and in mice in vivo (2.5-25 mg/kg, p.o.) in a DPYD-dependent manner via partial suppression of DNA repair by homologous recombination (HR).

Orally active dihydropyrimidine dehydrogenase (DPYD) inhibitor with cancer-radiosensitizing efficacy in vitro and in vivo.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable