SML2771

Amonafide

≥98% (HPLC)

• 동의어(들): 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, AS1413, FA 142, NSC 308847, Nafidimide
• 실험식(Hill 표기법): C₁₆H₁₇N₃O₂
• CAS Number: 69408-81-7
• Molecular Weight: 283.33
• MDL number: MFCD00866438
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: [n]1([c](c2c3c([c]1=O)cccc3cc(c2)N)=O)CCN(C)C
• InChI: 1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
• InChI key: UPALIKSFLSVKIS-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Amonafide, a naphthalimides DNA intercalator, is a potent topoisomerase II inhibitor that inhibits tumor proliferation and progression. It appears that Amonafide inhibits melanoma progression through inhibition of the AKT/mTOR signaling pathway.

DNA intercalator and potent topoisomerase II inhibitor

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable