SML3908

SLU-PP-332

≥98% (HPLC)

• 동의어(들): (E)-4-Hydroxy-N′(naphthalen-2-ylmethylene)benzohydrazide, 4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide, ERR pan-Agonist 332, SR9861
• 실험식(Hill 표기법): C₁₈H₁₄N₂O₂
• CAS Number: 303760-60-3
• Molecular Weight: 290.32
• MDL number: MFCD00595076
• UNSPSC 코드: 51111800
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• 저장 온도: 2-8°C
• SMILES string: OC1=CC=C(C=C1)C(N/N=C/C2=CC3=C(C=C2)C=CC=C3)=O
• InChI key: RNZIMBFHRXYRLL-XDHOZWIPSA-N

설명

생화학적/생리학적 작용

Non-toxic pan ERRα/β/γ agonist with significant ERRα activity that acts as an exercise mimetic.



SLU-PP-332 is a non-toxic pan ERRα/β/γ (estrogen receptor-related receptors α/β/γ) agonist with significant ERRα activity (EC50 = 98, 230 & 430 nM against ERRα, ERRβ & ERγ) and acts as an exercise mimetic. SLU-PP-332 displays selectivity over ERα, ERβ and several other closely related nuclear receptors. It induces Ddit4 expression and enhances mitochondrial respiration in C2C12 myocytes (10 µM) and exercise endurance in mice (50 mg/kg bid, ip) in an ERRα-dependent manner.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable