F8557
FK866 hydrochloride hydrate
≥98% (HPLC), powder, NAD biosynthesis inhibitor
동의어(들):
FK866 hydrochloride hydrate, (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide, K22.175
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C24H29N3O2·HCl · xH2O
CAS Number:
Molecular Weight:
427.97 (anhydrous basis)
MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.77
추천 제품
Product Name
FK866 hydrochloride hydrate, ≥98% (HPLC)
Quality Level
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
DMSO: 10 mg/mL, clear
저장 온도
−20°C
SMILES string
N2(CCC(CC2)CCCCNC(=O)\C=C\c3cnccc3)C(=O)c1ccccc1
InChI
1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChI key
KPBNHDGDUADAGP-VAWYXSNFSA-N
관련 카테고리
일반 설명
FK866 is used to treat inflammatory diseases and cancer.
애플리케이션
FK866 hydrochloride hydrate has been used:
- to investigate its effects on intra-axonal NAD+ levels
- to induce NAD+ depletion
- to reduce the level of tumor necrosis factor-α (TNF-α), nicotinamide phosphoribosyltransferase (NAMPT) and interleukin-6 (IL-6) in the ischemic brain tissue
생화학적/생리학적 작용
FK866 is a potent inhibitor of NAD biosynthesis, and a specific inhibitor of NAMPT (Nicotinamide Phosphoribosyltransferase, visfatin, PBEF). NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAMPT also acts as a cytokine independent of its enzymatic activity, playing a major part in regulating immune responses.
FK866 is a potent inhibitor of NAD biosynthesis.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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