SML3989

DRP1 Inhibitor, MIDI

≥98% (HPLC)

• 동의어(들): 1,1′-(1,4-Phenylene)bis[3-(3-pyridinyl)-2-propen-1-one], MIDI
• 실험식(Hill 표기법): C₂₂H₁₆N₂O₂
• CAS Number: 348145-43-7
• Molecular Weight: 340.37
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 0.5 mg/mL, clear (Warmed)
• 저장 온도: room temp
• SMILES string: O=C(/C=C/C1=CC=CN=C1)C2=CC=C(C(/C=C/C3=CC=CN=C3)=O)C=C2
• InChI key: IOESTAVFGVAMRH-YDWXAUTNSA-N

설명

생화학적/생리학적 작용

Mitochondrial fission inhibitor that blocks DRP1 recruitment to mitochondria.



DRP1 Inhibitor MIDI is a cell-permeable, symmetrical pyridinyl-propenone compound that acts as a potent, time-dependent mitochondrial fission inhibitor (0.5 - 2 µM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable