T2067

Tyrphostin AG 879

99% (HPLC)

• 동의어(들): α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
• 실험식(Hill 표기법): C₁₈H₂₄N₂OS
• CAS Number: 148741-30-4
• Molecular Weight: 316.46
• MDL number: MFCD00236450
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278728
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: 99% (HPLC)
• solubility: DMSO: soluble (at 26 mg/ml); H₂O: insoluble
• SMILES string: CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C
• InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
• InChI key: XRZYELWZLNAXGE-KPKJPENVSA-N
• 유전자 정보: human ... ERBB2(2064), NTRK1(4914)

설명

애플리케이션

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation¹. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation².

생화학적/생리학적 작용

Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells³. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice⁴.

특징 및 장점

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제조 메모

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)