QBD10903

Fmoc-N-amido-dPEG^®₃₆-acid

>95% (HPLC)

• Synonym(s): Fmoc-N-amido-PEG₃₆-acid, Fmoc-NH-PEG₃₆-acid, Fmoc-PEG-acid, Fmoc-PEG₁₅₀₀-acid, Fmoc-PEG₃₆-acid
• Empirical Formula (Hill Notation): C₉₀H₁₆₁NO₄₀
• Molecular Weight: 1897.22
• MDL number: MFCD21363317
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• assay: >95% (HPLC)
• form: solid or viscous liquid
• reaction suitability: reaction type: Pegylations
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C90H161NO40/c92-89(93)9-11-95-13-15-97-17-19-99-21-23-101-25-27-103-29-31-105-33-35-107-37-39-109-41-43-111-45-47-113-49-51-115-53-55-117-57-59-119-61-63-121-65-67-123-69-71-125-73-75-127-77-79-129-81-82-130-80-78-128-76-74-126-72-70-124-68-66-122-64-6
• InChI key: XXEJJMXFEIKVOC-UHFFFAOYSA-N

Description

Features and Benefits

Fmoc-N-amido-dPEG₃₆-acid is a monodisperse PEG product that is useful for peptide synthesis. The 112-atom dPEG spacer allows the introduction of a long, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. Fmoc-N-amido-dPEG₃₆-acid is the monodisperse PEG equivalent of polymeric PEG₁₅₀₀. This product is part of the Fmoc-N-amido-dPEG_n-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable