C1494

Carmofur

≥98% (HPLC), powder

• Synonyme(s) : 1-Hexylcarbamoyl-5-fluorouracil, HCFU
• Formule empirique (notation de Hill) : C₁₁H₁₆FN₃O₃
• CAS Number: 61422-45-5
• Poids moléculaire : 257.26
• Numéro MDL: MFCD00866284
• Code UNSPSC : 12352200
• ID de substance PubChem : 329774890
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: DMSO: >15 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
• InChI: 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
• Clé InChI: AOCCBINRVIKJHY-UHFFFAOYSA-N

Description

Application

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

Actions biochimiques/physiologiques

Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (M^pro) in vitro.

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Carmofur is an antineoplastic agent and a flurorouracil analog.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H361
• Conseils de prudence: P201 - P301 + P310 + P330
• Classification des risques: Acute Tox. 3 Oral - Repr. 2
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable