H5653

8-Hydroxy-2′-deoxyguanosine

≥98% (TLC), DNA damage biomaker

• Synonyme(s) : 8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
• Formule empirique (notation de Hill) : C₁₀H₁₃N₅O₅
• CAS Number: 88847-89-6
• Poids moléculaire : 283.24
• Numéro MDL: MFCD00210311
• Code UNSPSC : 12352200
• ID de substance PubChem : 24895702
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: 8-Hydroxy-2′-deoxyguanosine, ≥98% (TLC)
• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1
• InChI: 1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)
• Clé InChI: HCAJQHYUCKICQH-UHFFFAOYSA-N

Description

Application

8-Hydroxy-2′-deoxyguanosine has been used:

• as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
• as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
• as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo
• as a standard for LC/MS/MS analysis

Actions biochimiques/physiologiques

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer. Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)