D7145

2′-Deoxyguanosine monohydrate

99-100%

• Synonyme(s) : 2′-Deoxyguanosine hydrate, 9-(2-Deoxy-β-D-ribofuranosyl)guanine, Guanine-2′-deoxyriboside
• Formule empirique (notation de Hill) : C₁₀H₁₃N₅O₄ · H₂O
• CAS Number: 312693-72-4
• Poids moléculaire : 285.26
• Beilstein: 39814
• Numéro MDL: MFCD00150760
• Code UNSPSC : 41106305
• ID de substance PubChem : 24894083
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: 99-100%
• Forme: powder
• Solubilité: 1 M NH₄OH: 50 mg/mL, clear, colorless
• Chaîne SMILES: O.NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1
• InChI: 1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1
• Clé InChI: LZSCQUCOIRGCEJ-FPKZOZHISA-N

Description

Application

2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:

• to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish,
• in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis,
• in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes

Actions biochimiques/physiologiques

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphorylation (kinases) forms deoxyguanosine triphosphate (dGTP) which is used by DNA polymerases and reverse transcriptases to synthesize DNA(s). Deoxyguanosine is the most electron-rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable