SML1409

Madrasin

≥98% (HPLC)

• Synonyme(s) : 2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-3H-pyrimidin-4-one, 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone (9CI), 4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-(9CI), 4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-, DDD00107587, RNAsplicing inhibitor
• Formule empirique (notation de Hill) : C₁₆H₁₇N₅O₂
• CAS Number: 374913-63-0
• Poids moléculaire : 311.34
• Numéro MDL: MFCD02233199
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825856
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: , white to dark brown
• Solubilité: DMSO: 0.5 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1=NC(NC(NC(C)=C2C)=NC2=O)=NC3=CC(OC)=CC=C31
• InChI: 1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
• Clé InChI: QQJIYKXTEMDJFM-UHFFFAOYSA-N

Description

Application

Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.

Actions biochimiques/physiologiques

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.

Madrasin is a potent and cell penetrant splicing inhibitor.

Madrasin is considered toxic to the cell at a higher concentration. At its minimal concentration, madrasin is known to induce subnuclear protein localization and cause cell cycle arrest.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable