T6575

TOFA

≥98% (HPLC)

• Synonyme(s) : 5-(Tetradecyloxy)-2-furoic acid
• Formule empirique (notation de Hill) : C₁₉H₃₂O₄
• CAS Number: 54857-86-2
• Poids moléculaire : 324.45
• Numéro MDL: MFCD01726059
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826849
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Pf: 112-115 °C
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: CCCCCCCCCCCCCCOc1ccc(o1)C(O)=O
• InChI: 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
• Clé InChI: CZRCFAOMWRAFIC-UHFFFAOYSA-N

Description

Application

TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).

TOFA has been used as an ACC inhibitor to study its effect on insulin secretion in INS-1E cells.

Actions biochimiques/physiologiques

5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.

Studies have reported that TOFA can inhibit the anorectic effect of subcutaneous tamoxifen (TMX) on food intake during refeeding experiments in rats.

TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC).

TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC). TOFA is a key enzyme involved in fatty acid biosynthesis. TOFA inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀ = 4 μM in human breast cancer cell line MCF7).

Notes préparatoires

TOFA is soluble in DMSO at a concentration that is greater than 2 mg/ml.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)