T7750

2-Thiouracile

≥99%

• Synonyme(s) : (2-thioxo -2, 3-dihydropyrimidin-4(1H)-one), 2TU, 4-Hydroxy-2-mercaptopyrimidine
• Formule empirique (notation de Hill) : C₄H₄N₂OS
• CAS Number: 141-90-2
• Poids moléculaire : 128.15
• Beilstein: 112227
• Numéro CE : 205-508-8
• Numéro MDL: MFCD00006039
• Code UNSPSC : 41106305
• ID de substance PubChem : 24900470
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: ≥99%
• Forme: powder
• Pf: >300 °C (lit.)
• Solubilité: 1 M NaOH: 5 mg/mL, clear to very slightly hazy; 1 M NaOH: 50 mg/mL, colorless to faintly yellow
• Chaîne SMILES: O=C1NC(=S)NC=C1
• InChI: 1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
• Clé InChI: ZEMGGZBWXRYJHK-UHFFFAOYSA-N

Description

Description générale

2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase.This antithyroid drug has less solubility in H₂O & organic solvents.

Application

2-Thiouracil may be used:

• in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS)
• to study its electro-oxidation and determination at titanium dioxide (TiO2) nanoparticles-modified gold electrode
• to study the effect of methylation on the deactivation mechanism or the triplet-state dynamics of 2-thiouracil using time-resolved photoelectron spectroscopy

Actions biochimiques/physiologiques

2-Thiouracil acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), chromium (Cr), zinc (Zn), and silver (Ag).2-thiouracil can be incorporated into the tissue culture medium to inhibit virus replication or movement from infected to healthy tissues during chemotherapy.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H351
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Carc. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges