15205

Blasticidine S hydrochloride

• 동의어(들): Blasticidin S
• 실험식(Hill 표기법): C₁₇H₂₆N₈O₅ · HCl
• CAS Number: 3513-03-9
• Molecular Weight: 458.90
• MDL number: MFCD02091640
• UNSPSC 코드: 51102829
• PubChem Substance ID: 57647341
• NACRES: NA.76

속성

• 양식: powder
• Quality Level: 200
• 색상: white to off-white
• solubility: acetic acid: water: soluble, clear, colorless
• 항생제 활성 스펙트럼: fungi
• 응용 분야: agriculture; environmental
• 동작 모드: protein synthesis | interferes
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N
• InChI: 1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1
• InChI key: YQXYQOXRCNEATG-ZAYJLJTISA-N

설명

일반 설명

Blasticidin S belongs to the aminoacylnucleoside class of antibiotics. It inhibits protein synthesis in bacteria and eukaryotes. It also has fungicidal properties and prevents rice blast disease.

Chemical structure: nucleoside

애플리케이션

Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells . It is also used to study protein synthesis at the level of peptide bond formation.

생화학적/생리학적 작용

Blasticidin S inhibits hydrolysis of peptidyl-tRNA induced by release factors. It enhances the binding of tRNA to the large subunit of ribosomes and to an extent inhibits peptide bond formation.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 1 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges