B6179

Bongkrekic acid solution

from Pseudomonas cocovenenans, ≥95% (HPLC), solution, adenine nucleotide translocase inhibitor

• 실험식(Hill 표기법): C₂₈H₃₈O₇
• CAS Number: 11076-19-0
• Molecular Weight: 486.60
• MDL number: MFCD01729616
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24891898
• NACRES: NA.77

속성

• Product Name: Bongkrekic acid solution, from Pseudomonas cocovenenans, ≥95% (HPLC), ~1 mg/mL
• 생물학적 소스: Pseudomonas cocovenenans
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: solution
• 농도: ~1 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: CO[C@H](C/C=C\C=C\CC\C=C\C[C@H](C)\C=C\C(CC(O)=O)=C/C(O)=O)\C(C)=C/C=C(\C)C(O)=O
• InChI: 1S/C28H38O7/c1-21(15-18-24(19-26(29)30)20-27(31)32)13-11-9-7-5-6-8-10-12-14-25(35-4)22(2)16-17-23(3)28(33)34/h6,8-12,15-19,21,25H,5,7,13-14,20H2,1-4H3,(H,29,30)(H,31,32)(H,33,34)/b8-6+,11-9+,12-10-,18-15+,22-16-,23-17+,24-19+/t21-,25+/m0/s1
• InChI key: SHCXABJSXUACKU-WUTQZGRKSA-N

설명

애플리케이션

Bongkrekic acid solution has been used as an adenine nucleotide translocator (ANT) inhibitor to find out a different approach for the inhibition of oxidative phosphorylation in intact T98G cells. It has also been used as an inhibitor of the permeabilization transition pore complex (PTPC) pore and a tool to explore the role of PTPC in induction of apoptosis.

생화학적/생리학적 작용

An antiapoptotic agent, it protects against NMDA receptor induced neuronal apoptosis,^­ extends cell survival in cells undergoing apoptosis following infection with viral vectors and abrogates apoptosis induced by hydrogen peroxide in T-cells. It is an inhibitor of adenine nucleotide translocase, which is a component of the mitochondrial permeability transition (MPT) pore complex. Bongkrekic acid prevents mitochondrial depolarization, swelling, rupture of mitochondrial outer membrane, and release of apoptogenic proteins such as cytochrome c. This phenomenon was observed during staurosporine induced apoptosis in Jurkat cells, in HepG2 undergoing apoptosis following TNF-α and ethanol.

특징 및 장점

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기타 정보

The toxic principle of P. cocovenenans.

물리적 형태

Solution in 0.01 M Tris buffer, pH 7.5.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)