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주요 문서

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C5438

8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt

Name: 8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt
Brand: SIGMA

≥95% (HPLC), powder

동의어(들):

8-pCPT-cGMP, pCPT-cGMP

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모든 사진(2)

About This Item

실험식(Hill 표기법):

C₁₆H₁₄ClN₅NaO₇PS

CAS Number:

51239-26-0

Molecular Weight:

509.79

MDL number:

MFCD00674888

UNSPSC 코드:

41106305

PubChem Substance ID:

24892786

NACRES:

NA.77

추천 제품

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Sigma-Aldrich

B1381

8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt

Sigma-Aldrich

B7880

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt

Sigma-Aldrich

28745-M

Adenosine 3′,5′-cyclic Monophosphate, N⁶,O^2′-Dibutyryl-, Sodium Salt

Sigma-Aldrich

A6885

Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate

Sigma-Aldrich

SML3033

Sildenafil citrate

Sigma-Aldrich

D5431

Diethylamine NONOate diethylammonium salt

Sigma-Aldrich

C7698

Cycloheximide

Sigma-Aldrich

A9501

Adenosine 3′,5′-cyclic monophosphate

Sigma-Aldrich

C3912

8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt

Sigma-Aldrich

C4859

Cycloheximide solution

Quality Level

200

분석

≥95% (HPLC)

양식

powder

색상

white

solubility

H₂O: 25 mg/mL

저장 온도

−20°C

SMILES string

[Na+].NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5COP([O-])(=O)O[C@H]5[C@H]4O)C(=O)N1

InChI

1S/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1

InChI key

REEQGIQRCDWDRA-ZBMQJGODSA-M

애플리케이션

8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt has been used to activate GMP-dependent protein kinase (PKG) in vascular smooth muscle cells (VSMCs).

생화학적/생리학적 작용

Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.