H7166

IL-3 human

HumanKine^®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

• 동의어(들): Interleukin-3 human, IL-3
• MDL number: MFCD00147276
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Product Name: Interleukin-3 human, IL-3, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in HEK 293 cells
• 분석: >95% (SDS-PAGE)
• 양식: lyophilized powder
• 효능: ≤2 ng/mL EC₅₀
• 품질: endotoxin tested
• 분자량: dimer 17-45 kDa (glycosylated)
• 포장: pkg of 10 μg
• 제조업체/상표: HumanZyme
• 기술: cell culture | mammalian: suitable
• 불순물: <1 EU/μg
• UniProt 수납 번호: P08700
• 저장 온도: −20°C
• 유전자 정보: human ... IL3(3562)

설명

생화학적/생리학적 작용

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.

Interleukin-3 is a multifunctional protein produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and induce IgG secretion from activated B cells.

물리적 형태

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

제조 메모

HumanKine Interleukin-3 (IL-3), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 17-45 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation which contributes to stability in cell growth media and other applications.

분석 메모

The activity was determined by the dosedependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

법적 정보

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable