790443

TCO-PEG3-maleimide

• 동의어(들): trans-Cyclooctene-maleimide
• 실험식(Hill 표기법): C₂₆H₄₁N₃O₈
• Molecular Weight: 523.62
• MDL number: MFCD28053553
• UNSPSC 코드: 12352111
• PubChem Substance ID: 329768215
• NACRES: NA.22

속성

• 양식: liquid
• Quality Level: 100
• 반응 적합성: reaction type: click chemistry; reagent type: linker
• 작용기: maleimide
• 저장 온도: −20°C
• SMILES string: O=C(NCCCOCCOCCOCCCNC(CCN1C(C=CC1=O)=O)=O)OC2CCC/C=C/CC2
• InChI: 1S/C26H41N3O8/c30-23(12-15-29-24(31)10-11-25(29)32)27-13-6-16-34-18-20-36-21-19-35-17-7-14-28-26(33)37-22-8-4-2-1-3-5-9-22/h1-2,10-11,22H,3-9,12-21H2,(H,27,30)(H,28,33)/b2-1+
• InChI key: BJZRPWAVCDJCTC-OWOJBTEDSA-N

설명

생화학적/생리학적 작용

Maleimide (thiol reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into thiol containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1; 2; 4; 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility; less aggregation and an increased distance between the thiol to be modified and the reactive alkene.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable