SML1075

Atglistatin

≥98% (HPLC), powder, adipose triglyceride lipase inhibitor

• 동의어(들): 3-(4′-(Dimethylamino)-[1,1′-biphenyl]-3-yl)-1,1-dimethylurea
• 실험식(Hill 표기법): C₁₇H₂₁N₃O
• CAS Number: 1469924-27-3
• Molecular Weight: 283.37
• MDL number: MFCD28009494
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825457
• NACRES: NA.77

속성

• Product Name: Atglistatin, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O
• InChI: 1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
• InChI key: AWOPBSAJHCUSAS-UHFFFAOYSA-N

설명

애플리케이션

Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).

생화학적/생리학적 작용

Atglistatin is a selective inhibitor of adipose triglyceride lipase (ATGL).

Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC₅₀ of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.

기타 정보

Produced under the license of University of Graz/Graz University of Technolog

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable