T123

Thioperamide maleate salt

solid

• 동의어(들): MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
• 실험식(Hill 표기법): C₁₅H₂₄N₄S · C₄H₄O₄
• CAS Number: 148440-81-7
• Molecular Weight: 408.52
• MDL number: MFCD00083209
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277809
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated; under inert gas
• 색상: white
• solubility: H₂O: >10 mg/mL; DMSO: 12 mg/mL; ethanol: 3 mg/mL
• SMILES string: OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
• InChI: 1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: REZRBLGMJZZSID-BTJKTKAUSA-N
• 유전자 정보: human ... HRH3(11255)

설명

애플리케이션

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

생화학적/생리학적 작용

Potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier.

Thioperamide is a potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

특징 및 장점

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves