D5287

2′-Deoxyinosine

≥98%

• Synonyme(s) : 9-(2-Deoxy-β-D-ribofuranosyl)hypoxanthine
• Formule empirique (notation de Hill) : C₁₀H₁₂N₄O₄
• CAS Number: 890-38-0
• Poids moléculaire : 252.23
• Beilstein: 33517
• Numéro CE : 212-964-1
• Numéro MDL: MFCD00005762
• Code UNSPSC : 41106305
• ID de substance PubChem : 24893935
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥98%
• Forme: powder
• Impuretés: inosine, essentially free
• Solubilité: 1 M NH₄OH: 50 mg/mL, clear, colorless
• Température de stockage: −20°C
• Chaîne SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23
• InChI: 1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
• Clé InChI: VGONTNSXDCQUGY-RRKCRQDMSA-N

Description

Application

2′-Deoxyinosine has been used in the quantification of nucleoside forms of DNA lesion in a single DNA sample by liquid chromatography tandem mass spectrometry (LC-MS/MS). It has also been used as a standard for high performance liquid chromatography analysis.

Actions biochimiques/physiologiques

2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. 2′-Deoxyinosine in DNA can arise from deamination of adenosine. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability.

2′-Deoxyinosine is a nucleoside form of hypoxanthine. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinosine is formed from nitrosative deamination by N₂O₃.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)